Interdisciplinary
Program in
Neuroscience
두뇌 및 신경계를 탐구하는 서울대학교 뇌과학협동과정
Interdisciplinary
Program in
Neuroscience
두뇌 및 신경계를 탐구하는 서울대학교 뇌과학협동과정
이승재 Ph.D.
교수
| 의과대학 의과학과
sjlee66@snu.ac.kr
전화번호:
(82)2-3668-7037 (Lab)
서울특별시 종로구 대학로 103
서울대학교 의과대학
융합관 402호
Neurological Disorder
소속의과대학 의과학과
의과대학 의학과
자연과학대학 뇌과학협동과정
2021
Wulansari N, Darsono WHW, Woo HJ, Chang MY, Kim J, Bae EJ, Sun W, Lee JH, Cho IJ, Shin H, Lee SJ*, Lee SH*. Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked DNAJC6 mutations. Sci Adv. 2021 doi: 10.1126/sciadv.abb1540. (*co-corresponding authors)
2019
Timo Strohäker, Byung Chul Jung, Shu-Hao Liou, Claudio O. Fernandez, Dietmar Riedel, Stefan Becker, Glenda M. Halliday, Marina Bennati, Woojin S. Kim*,Seung-Jae Lee*, and Markus Zweckstetter*. Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nat Commun. 2019;10(1):5535. doi: 10.1038/s41467-019-13564-w. (*co-corresponding authors)
2019
Jun Sung Lee, Kazuaki Kanai, Mari Suzuki, Woojin S. Kim, Han Soo Yoo, YuHong Fu, Dong-Kyu Kim, Byung Chul Jung, Minsun Choi, Kyu Won Oh, Yuanzhe Li, Mitsuyoshi Nakatani, Tomoko Nakazato, Satoko Sekimoto, Manabu Funayama, Hiroyo Yoshino, Shin-ichiro Kubo, Kenya Nishioka, Ryusuke Sakai, Morio Ueyama, Hideki Mochizuki, He-Jin Lee, Sergio Pablo Sardi, Glenda M. Halliday, Yoshitaka Nagai, Phil Hyu Lee, Nobutaka Hattori and Seung-Jae Lee. Arylsulfatase A, a genetic modifier of Parkinson’s disease, is an a-synuclein chaperone. BRAIN. 2019, doi: 10.1093/brain/awz205
2018
Bae E-J, Kim D-K, Kim C, Mante M, Adame A, Rockenstein E, Ulusoy A, Klinkenberg M, Jeong GR, Bae JR, Lee C, Lee H-J, Lee B-D, Di Monte DA, Masliah E, Lee S-J. LRRK2 kinase regulates -synuclein propagation via RAB35 phosphorylation. Nature Commun, 9(1):3465. doi: 10.1038/s41467-018-05958-z
2018
Lim S, Kim H-J, Kim D-K, Lee S-J. Non-cell-autonomous actions of alpha-synuclein: implications in glial synucleinopathies. Prog Neurobiol, 2018, 169, 158-171
2016
Kim DK, Lim HS, Kawasaki I, Shim YH, Vaikath NN, El-Agnaf OMA, Lee HJ, Lee S-J. Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function. Autophagy, 2016, 12, 1849-1863
2015
Kim C, Rockenstein E, Spencer B, Kim H-K, Adame A, Trejo M, Stafa K, Lee H-J, Lee S-J,*, Masliah E,* (2015) Antagonizing neuronal Toll-like receptor 2 prevents synucleinopathy by activating autophagy. Cell Reports, 13, 771-782 *Co-corresponding authors
2015
Lee S-J, Masliah E (2015) Aggregates feel the strain. Nature, 522, 296-297
2014
Bae E-J, Yang N-Y, Song M, Lee CS, Lee H-J, Masliah E, Sardi SP, Lee S-J (2014) Glucocerebrosidase deficiency enhances cell-to-cell transmission of -synuclein. Nature Communications, 5:4755 doi: 10.1038/ncomms5755
2014
Lee H-J, Bae E-J, Lee S-J. (2014) Extracelullar a-synuclein: A novel and crucial factor in Lewy body diseases. Nature Rev. Neurol., doi:10.1038/nrneurol.2013.275
2013
Kim C, Ho D-H, Suk J-E, You S, Michael S, Kang J, Lee S, Masliah E, Hwang D, Lee H-J, Lee S-J (2013) Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nature Commun. 4:1562 | DOI: 10.1038/ncomms2534
2010
Lee S-J, Desplats P, Sigurdson C, Tsigelny I, Masliah E (2010) Cell-Cell Transmission of Non-Prion Protein Aggregates, Nature Review Neurology, 6, 702-706
2009
Desplats P*, Lee H-J*, Bae E-J, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee S-J (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc. Nat. Acad. Sci. USA, 106, 13010-13015 (* equal contribution) Cover highlight