Research Overview

2022

Hyunjoo Kim*, Muhah Jeong*, Do-Hyeong Na, Shin-Hyeon Ryu, Eun Il Jeong, Kwangmin Jung, Jaemin Kang, Ho-June Lee, Taebo Sim, Dae-Yeul Yu, Hee Chul Yu, Baik-Hwan Cho, Yong-Keun Jung (2022). AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis. Cell Death & Disease, 13(5), 469.

2022

Jihoon Nah, Akihiro Shirakabe, Risa Mukai, Peiyong Zhai, Eun-Ah Sung, Andreas Ivessa, Wataru Mizushima, Yasuki Nakada, Toshiro Saito, Chengchen Hu, Yong-Keun Jung, Junichi Sadoshima (2022). Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart. Cardiovascular Research, (),

2021

Jonghee Han, Junho Hyun, Jaesang Park, Sunmin Jung, Yoonseo Oh, Youbin Kim, Shin-Hyeon Ryu, Seo-Hyun Kim, Eun Il Jeong, Dong-Gyu Jo, Sung-Hye Park, Yong-Keun Jung (2021). Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer's disease. Cell Reports, 37(10), .

2021

Na Yeon Park, Doo Sin Jo, Yong Hwan Kim, Ji-Eun Bae, Joon Bum Kim, Hyun Jun Park, Ji Yeon Choi, Ha Jung Lee, Jeong Ho Chang, Heeyoun Bunch, Hong Bae Jeon, Yong-Keun Jung, Dong-Hyung Cho (2021). Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity. Archives of Pharmacal Research, 44(6), 621-631.

2021

Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E Adamopoulos, Khosrow Adeli, Timon E Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N Agrewala, Alexander Agrotis, Patricia V Aguilar, S Tariq Ahmad, Zubair M Ahmed, Ulises Ahumada-Castro, Yong-Keun Jung, etc. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), 1-382.

2021

Jisu Park*, Hyunwoo Choi*, Young Doo Kim, Seo-Hyun Kim, Youbin Kim, Youngdae Gwon, Dong Young Lee, Sung-Hye Park, Won Do Heo, Yong-Keun Jung (2021). Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. Molecular Psychiatry, (), .

2021

So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo, Dong-Hyung Cho (2021). Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells. Molecular Brain, 14(1), 6.

2020

Jung S*, Hyun J*, Nah J, Han J, Kim SH, Park J, Oh Y, Gwon Y, Moon S, Jo DG, Jung YK (2020). SERP1 Is an Assembly Regulator of γ-Secretase in Metabolic Stress Conditions. Science Signaling, 13(623), eaax8949.

2020

Seung-Min Yoo, Shun-Ichi Yamashita, Hyunjoo Kim, DoHyeong Na, Haneul Lee, Seo Jin Kim, Dong-Hyung Cho, Tomotake Kanki, Yong-Keun Jung (2020). FKBP8 LIRL-dependent Mitochondrial Fragmentation Facilitates Mitophagy Under Stress Conditions. FASEB Journal, 34(2), 2944-2957.

2020

Doo Sin Jo, So Jung Park, Ae-Kyeong Kim, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Hyun Jun Park, Ji Hyun Shin, Jong Wook Chang, Peter K Kim, Yong-Keun Jung, Jae-Young Koh, Seong-Kyu Choe, Kyu-Sun Lee, Dong-Hyung Cho. Loss of HSPA9 Induces Peroxisomal Degradation by Increasing Pexophagy. Autophagy, (2020), 1-15.

2020

Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Kim (2020). Ca2+-permeable TRPV1 Pain Receptor Knockout Rescues Memory Deficits and Reduces Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease. Human Molecular Genetics, 29(2), 228-237.

2020

Seung-Min Yoo, Jisu Park, Seo-Hyun Kim, Yong-Keun Jung (2020). Emerging Perspectives on Mitochondrial Dysfunction and Inflammation in Alzheimer's Disease. BMB Reports, 53(1), 35-46.

2019

Yong-Keun Jung (2019). Highlighting Apoptosis in Neuronal Injury. Biochemical and Biophysical Research Communications, 520(4), 681.

2019

Ji-Eun Bae, Gil Myung Kang, Se Hee Min, Doo Sin Jo, Yong-Keun Jung, Keetae Kim, Min-Seon Kim, Dong-Hyung Cho (2019). Primary Cilia Mediate Mitochondrial Stress Responses to Promote Dopamine Neuron Survival in a Parkinson's Disease Model. Cell Death & Disease, 10(12), 952.

2019

Song-Yi Lee, Hyunjoo Kim, Cathena Meiling Li, Jaemin Kang, Ayaz Najafov, Muhah Jung, Soosung Kang, Shaomeng Wang, Junying Yuan, Yong-Keun Jung (2019). Casein kinase-1γ1 and 3 Stimulate Tumor Necrosis Factor-Induced Necroptosis Through RIPK3. Cell Death & Disease, 10(12), 923.

2019

Ji Hyun Shin, So Jung Park, Doo Sin Jo, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Yoon Kyung Jo, Jung Jin Hwang, Jin-A Lee, Dong-Gyu Jo, Jin Cheon Kim, Yong Keun Jung, Jae-Young Koh, Dong-Hyung Cho (2019). Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation. Autophagy, 15(9), 1495-1505.

2019

Hyeonjeong Lee, Yumin Oh, Young-Jun Jeon, Song-Yi Lee, Hyunjoo Kim, Ho-June Lee, Yong-Keun Jung (2019). DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death.. Cancer Research, 79(11), 2839-2852.

2019

Hyeonjeong Lee, Yumin Oh, Young-Jun Jeon, Song-Yi Lee, Hyunjoo Kim, Ho-June Lee, Yong-Keun Jung (2019). DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death.. Cancer Research, 79(11), 2839-2852.

2019

Youngdae Gwon, Seo-Hyun Kim, Hyun Tae Kim, Tae-In Kam, Jisu Park, Bitna Lim, Hyunju Cha, Ho-Jin Chang, Yong Rae Hong, Yong-Keun Jung (2019). Amelioration of Amyloid β-FcγRIIb Neurotoxicity and Tau Pathologies by Targeting LYN. FASEB Journal, 33(3), 4300-4313.

2018

Youngdae Gwon, Tae-In Kam, Seo-Hyun Kim, Sungmin Song, Hyejin Park, Bitna Lim, Haneul Lee, Weontae Lee, Dong-Gyu Jo, Yong-Keun Jung (2018). TOM1 regulates neuronal accumulation of amyloid-β oligomers by FcγRIIb2 variant in Alzheimer’s disease. Journal of Neuroscience, 38(42), 9001-9018.

2018

Seung-Min Yoo, Yong-Keun Jung (2018). A molecular approach to mitophagy and mitochondrial dynamics. Molecules and Cells, 41(1), 18-26.