Research Overview

2022

Kwak S, Kim H, Oh DJ, Jeon YJ, Park SM, Lee JY. Clinical and biological subtypes of late-life depression. Journal of Affective Disorders. 2022 Jun 9.

2022

Bae M, Kim MS, Park S, Oh DJ, Lee JY. The Effect of the Medication Management Service On the Cognitive Change and Community Service Usage. Journal of Korean Geriatric Psychiatry.;26(1):23-7.

2022

Yoo SY, Han A, Park S, Lee JY. Incidence and Cognitive Decline of Alzheimer’s Disease and Other Dementia by Apolipoprotein ε4 Allele Presence: A Community-Based Cohort Study in Korean Elderly. Psychiatry Investigation. 2022 Mar 3;19(3):190-6.

2022

Ha J, Kwak S, Kim KY, Kim H, Cho SY, Kim M, Lee JY, Kim E. Relationship between adipokines, cognition, and brain structures in old age depending on obesity. The Journals of Gerontology: Series A. 2022.

2022

Kwak S, Oh DJ, Jeon YJ, Oh DY, Park SM, Kim H, Lee JY. Utility of Machine Learning Approach with Neuropsychological Tests in Predicting Functional Impairment of Alzheimer’s Disease. Journal of Alzheimer's Disease. 2022(Preprint):1-6.

2022

Kwak S, Shin SA, Ko H, Kim H, Oh DJ, Youn JH, Lee JY, Kim YK. A Comparison Between the Performances of Verbal and Nonverbal Fluency Tests in Discriminating Between Mild Cognitive Impairments and Alzheimer’s Disease Patients and Their Brain Morphological Correlates. Dementia and Neurocognitive Disorders. 2022 Jan;21(1):17.

2022

Kim KY, Kwak S, Ha J, Oh DJ, Kim M, Cho SY, Kim H, Lee JY, Kim E. Loss of association between plasma irisin levels and cognition in Alzheimer’s disease. Psychoneuroendocrinology. 2022 Feb 1;136:105624.

2021

Kwak S, Park SM, Jeon YJ, Ko HW, Oh DJ, Lee JY. Multiple Cognitive and Behavioral Factors Link Association Between Brain Structure and Functional Impairment of Daily Instrumental Activities in Older Adults. J Int Neuropsychol Soc. 2021;1-14 

2021

Ko HW, Kim KS, Bae MJ, Seo MG, Nam GY, Park SW, Park SH, Ihm J, Lee JY. Changes in Computer-Analyzed Facial Expressions with Age. Sensors. 2021;21(14):4858 

2021

Kim M, Park SW, Lee JY, Kim H, Rhim JH, Park SW, Lee JY, Son HC, Kim YK, Lee SH. Differences in Brain Morphology between Hydrocephalus Ex Vacuo and Idiopathic Normal Pressure Hydrocephalus. Psychiatry Investig. 2021;18(7):628–635 

2021

Kim JW, Byun MS, Yi D, Lee JH, Jeon SY, Ko K, Joung H, Jung G, Lee JY, Sohn CH, Lee YS, Kim YK, Lee DY. Blood Hemoglobin, in-vivo Alzheimer Pathologies, and Cognitive Impairment: A Cross-Sectional Study. Front Aging Neurosci. 2021;13:625511 

2021

Kim J, Shin E, Han K, Park S, Youn JH, Jin G, Lee JY. Efficacy of Smart Speaker–Based Metamemory Training in Older Adults: Case-Control Cohort Study. J Med Internet Res. 2021;23(2):e20177 

2021

Song HY, Park SW, Jo SY, Lee JI, Han SJ, Choi IW, Lee JY. Is Anxiety-Inducing VR Experienced Differently Depending on Personality? The Mediating Role of Presence. IEEE Access. 2021;9:42161-42168 

2020

Kang KM, Byun MS, Lee JH, Yi D, Choi HJ, Lee E, Lee Y, Lee JY, Kim YK, Sohn BK, Sohn CH, Lee DY. Association of carotid and intracranial stenosis with Alzheimer's disease biomarkers. Alzheimers Res Ther. 2020;12(1):106 

2020

Ha J, Moon MK, Kim H, Park M, Cho SY, Lee J, Lee JY, Kim E. Plasma Clusterin as a Potential Link Between Diabetes and Alzheimer Disease. J Clin Endocrinol Metab. 2020;105(9):378 

2020

Lee SY, Kang JM, Kim DJ, Woo SK, Lee JY, Cho SJ. Cognitive Reserve, Leisure Activity, and Neuropsychological Profile in the Early Stage of Cognitive Decline. Front Aging Neurosci. 2020;12:590607 

2020

Yun Y, Lee SY, Choi WH, Park JC, Lee DH, Kim YK, Lee JH, Lee JY, Lee MJ, Kim YH. Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus. J Alzheimers Dis. 2020;78(1):195-205 

2020

Lee SY, Kim H, Lee JY, Kim JH, Lee DY, Mook-Jung I, Kim YH, Kim YK. Effects of Chronic Tinnitus on Metabolic and Structural Changes in Subjects With Mild Cognitive Impairment. Front Aging Neurosci. 2020;12:594282 

2020

Lee JH, Byun MS, Yi D, Ko K, Jeon SY, Sohn BK, Lee JY, Lee Y, Joung H, Lee DY. Long-Term Exposure to PM10 and in vivo Alzheimer's Disease Pathologies. J Alzheimers Dis. 2020;78(2):745-756 

2020

Lee I, Na HR, Byun BH, Lim I, Kim BI, Choi CW, Ko IO, Lee KC, Kim KM, Park SY, Kim YK, Lee JY, Bu SH, Kim JH, Kil HS, Park C, Chi DY, Ha JH, Lim SM.. Clinical Usefulness of 18F-FC119S Positron-Emission Tomography as an Auxiliary Diagnostic Method for Dementia: An Open-Label, Single-Dose, Evaluator-Blind Clinical Trial. J Clin Neurol. 2020;16(1):131-139 

2020

Youn JH, Park S, Lee JY, Cho SJ, Kim J, Ryu SH. Cognitive Improvement in Older Adults with Mild Cognitive Impairment: Evidence from a Multi-Strategic Metamemory Training. J Clin Med. 2020;9(2):362 

2020

Kim A, Kim S, Park KW, Park KH, Youn YC, Lee DW, Lee JY, Lee JH, Jeong JH, Choi SH, Han HJ, Kim S, Na S, Park M, Yim HW, Yang DW. Reliability and Validity of a Short Form of the Korean Dementia Screening Questionnaire-Cognition.. J Clin Neurol. 2020;16(1):145-153 

2020

Ryu SY, Kim A, Kim SY, Park KW, Park KH, Youn YC, Lee DW, Lee JY, Lee JH, Jeong JH, Choi SH, Han HJ, Kim S, Na S, Park M, Yim HW, Yang DW. Self- And Informant-Reported Cognitive Functioning and Awareness in Subjective Cognitive Decline, Mild Cognitive Impairment, and Very Mild Alzheimer Disease. Int J Geriatr Psychiatry. 2020;35(1):91-98 

2020

Kim JW, Byun MS, Yi D, Lee JH, Ko K, Jeon SY, Sohn BK, Lee JY, Kim YK, Shin SA, Sohn CH, Lee DY. Association of Moderate Alcohol Intake With in Vivo Amyloid-Beta Deposition in Human Brain: A Cross-Sectional Study. PLoS One. 2020;17(2):e1003022 

2020

Park S, Lee K, Lim JA, Ko H, Kim T, Lee JI, Kim H, Han SJ, Kim JS, Park S, Lee JY, Lee EC. Differences in Facial Expressions between Spontaneous and Posed smiles: Automated Method by Action Units and three-dimensional Facial Landmarks. Sensors. 2020;20:1199 

2020

Jeon SY, Byun MS, Yi D, Lee JH, Ko K, Sohn BK, Lee JY, Ryu SH, Lee DW, Shin SA, Kim YK, Kang KM, Sohn CH, Lee DY. Midlife Lifestyle Activities Moderate APOE4 Effect on in vivo Alzheimer’s Disease Pathologies. Front Aging Neurosci. 2020;12:42 

2020

Oh SJ, Lee JY, Kim DK. The Design of CNN Architectures for Optimal Six Basic Emotion Classification Using Multiple Physiological Signals. Sensors. 2020;20(3):866 

2020

Na KS, Cho SE, Hong JP, Lee JY, Chang SM, Jeon HJ, Cho SJ. Association between personality traits and suicidality by age groups in a nationally representative Korean sample. Medicine. 2020;99(16):19161 

2020

Kim JW, Byun MS, Yi D, Lee JH, Jeon SY, Ko K, Jung G, Lee HN, Lee JY, Sohn CH, Lee YS, Shin SA, Kim YK, Lee DY. Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment. Front Aging Neurosci. 2020;12:160 

2020

Lee SH, Byun MS, Lee JH, Yi D, Sohn BK, Lee JY, Kim YK, Shin SA, Sohn CH, Lee DY. Sex-Specific Association of Lifetime Body Mass Index with Alzheimer's Disease Neuroimaging Biomarkers. J Alzheimers Dis. 2020;75(3):767-777 

2020

Kang KM, Sohn CH, Byun MS, Lee JH, Yi D, Lee Y, Lee JY, Kim YK, Sohn BK, Yoo RE, Yun TJ, Choi SH, Kim JH, Lee DY. Prediction of Amyloid Positivity in Mild Cognitive Impairment Using Fully Automated Brain Segmentation Software. Neuropsychiatr Dis Treat. 2020;16:1745-1754 

2020

Kim JW, Byun MS, Lee JH, Yi D, Jeon SY, Sohn BK, Lee JY, Shin SA, Kim YK, Kang KM, Sohn CH, Lee DY. . Neurology. 2020;95(7):815-826 

2020

Kwak S, Park S, Kim J, Park S, Lee JY. Multivariate neuroanatomical correlates of behavioral and psychological symptoms in dementia and the moderating role of education. Neuroimage Clin. 2020;28:102452 

2019

Jeon SY, Byun MS, Yi D, Lee JH, Choe YM, Ko K, Sohn BK, Choi HJ, Lee JY, Lee DY. Influence of hypertension on brain amyloid deposition and Alzheimer's disease signature neurodegeneration  Alzheimer’s disease signature neurodegeneration. Neurobiol Aging. 2019;75:62-70

2019

Byun MS, Kim HJ, Yi D, Choi HJ, Baek H, Lee JH, Choe YM, Lee SH, Ko K, Sohn BK, Lee JY, Lee Y, Kim YK, Lee YS, Lee DY. Region-specific association between basal blood insulin and cerebral glucose metabolism in older adults. Neuroimage Clin. 2019;22:1-8 

2019

Lee JY, Lee H, Yoo HB, Choi JS, Jung HY, Yoon EJ, Kim H, Jung YH, Lee HY, Kim YK. Efficacy of Cilostazol Administration in Alzheimer's Disease Patients with White Matter Lesions: A Positron-Emission Tomography Study. Neurotherapeutics. 2019;16(2):394-403 

2019

Youn JH, Ryu SH, Lee JY, Park S, Cho SJ, Kwon H, Yang JJ, Lee JM, Lee J, Kim S, Livingston G, Yoon DH. Brain structural changes after multi-strategic metamemory training in older adults with subjective memory complaints: A randomized controlled trial. Brain Behav. 2019;9(5):e01278 

2019

Lee SY, Lee JY, Han SY, Seo Y, Shim YJ, Kim YH.. Neurocognition of Aged Patients With Chronic Tinnitus: Focus on Mild Cognitive Impairment.. Clin Exp Otorhinolaryngol. 2019;epub: 

2019

Koo BK, Kim LK, Lee JY, Moon MK. Taking metformin and cognitive function change in older patients with diabetes. Geriatr Gerontol Int. 2019;19(8):755-761 

2019

Woo J, Hong JP, Cho SJ, Lee JY, Joen HJ, Kim BS, Chang SM.. Bidirectional Association between First-Episode Panic Disorder and Major Depressive Disorder in a Nationwide General Population Survey in Korea.. J Korean Med Sci. 2019;34(26):e181 

2019

Kim JW, Byun MS, Yi D, Lee JH, Jeon SY, Jung G, Lee HN, Sohn BK, Lee JY, Kim YK, Shin SA, Sohn CH, Lee DY; KBASE Research Group... Coffee intake and decreased amyloid pathology in human brain.. Transl Psychiatry. 2019;9(1):270 

2019

Park JE, Kim BS, Kim KW, Hahm BJ, Sohn JH, Suk HW, Lee JY, Cho MJ. Decline in the Incidence of All-Cause and Alzheimer’s Disease Dementia: a 12-Year-Later Rural Cohort Study in Korea. J Korean Med Sci. 2019;34(44):e293 

2019

Park S, Lee JH, Lee J, Cho Y, Park HG, Yoo Y, Youn JH, Ryu SH, Hwang JY, Kim J, Lee JY. Interactions between subjective memory complaint and objective cognitive deficit on memory performances. BMC Geriatr. 2019;19(1):294 

2019

Ahn YB, Yi D, Joung H, Seo EH, Lee YH, Byun MS, Lee JH, Jeon SY, Lee JY, Sohn BK, Lee DY. Normative Data for the Logical Memory Subtest of the Wechsler Memory Scale-IV in Middle-Aged and Elderly Korean People. Psychiatry Investig. 2019;16(11):793-799 

2018

Kong SH, Park YJ, Lee JY, Cho NH, Moon MK.. Insulin Resistance is Associated with Cognitive Decline Among Older Koreans with Normal Baseline Cognitive Function: A Prospective Community-Based Cohort Study. Sci Rep. 2018;8(1):650

2018

Yoo Y, Park HJ, Park S, Cho MJ, Cho SJ, Lee JY, Choi SH, Lee JY.. Interpersonal trauma moderates the relationship between personality factors and suicidality of individuals with posttraumatic stress disorder.. PLoS One. 2018;13(1):e0191198

2018

Park S, Ryu SH, Yoo Y, Yang JJ, Kwon H, Youn JH, Lee JM, Cho SJ, Lee JY.. Neural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaints. Sci Rep. 2018;8(1):1095

2018

Lee J, Sohn BK, Lee H, Seong SJ, Park S, Lee JY. Attachment style and filial obligation in the burden of caregivers of dementia patients.. Arch Gerontol Geriatr. 2018;75:104-111

2018

Sohn BK, Oh YK, Choi JS, Song J, Lim A, Lee JP, An JN, Choi HJ, Hwang JY, Jung HY, Lee JY, Lim CS.. Effectiveness of group cognitive behavioral therapy with mindfulness in end-stage renal disease hemodialysis patients. Kidney Res Clin Pract. 2018;37(1):77-84

2018

Jo S, Park S, Youn JH, Sohn BK, Choi HJ, Lee JY, Lee JY, Lee JY. The Mental Health Status and Intellectual Ability of Unwed Mothers Dwelling in Korean Shelter Homes. Int J Environ Res Public Health. 2018;15(4):637

2018

Jung YH, Kim H, Jeon SY, Kwon JM, Lee WJ, Kim YC, Jang JH, Choi SH, Lee JY, Kang DH. Brain Metabolites and Peripheral Biomarkers Associated with Neuroinflammation in Complex Regional Pain Syndrome Using [11C]-(R)-PK11195 Positron Emission Tomography and Magnetic Resonance Spectroscopy: A Pilot Study.. Pain Med. 2018;0(0):1-11

2018

Han C, Park M, Lee JY, Jung JY, Park SM, Choi JS. Dysfunctional information processing in individuals with acute exposure to sexual abuse An ERP study. Medicine. 2018;97(22):e10880

2018

Yoon DH, Lee JY, Shin SA, Kim YK, Song W. Physical Frailty and Amyloid-β Deposits in the Brains of Older Adults with Cognitive Frailty. J Clin Med. 2018;7(7):169

2018

Yoon DH, Lee JY, Song W. Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial. J Nutr Health Aging. 2018;:

2018

Kang JM, Lee JY, Kim YK, Sohn BK, Byun MS, Choi JE, Son SK, Im HJ, Lee JH, Ryu YH, Lee DY. Visual Rating and Computer-Assisted Analysis of FDG PET in the Prediction of Conversion to Alzheimer’s Disease in Mild Cognitive Impairment. Mol Diagn Ther. 2018;22:475-483

2018

Kim SH, Yang JS, Lee JC, Lee JY, Lee JY, Kim E, Moon MH. Lipidomic alterations in lipoproteins of patients with mild cognitive impairment and Alzheimer’s disease by asymmetrical flow field-flow fractionation and nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2018;1568:91-100

2018

Sohn BK, Park SM, Park IJ, Hwang JY, Choi JS, Lee JY, Jung HY. The Relationship between Emotional Labor and Job Stress among Hospital Workers. J Korean Med Sci. 2018;33(39):246-255

2018

Park S, Pyo S, Shin SA, Lee JY, Kim YK, Park HJ, Youn JH, Park SW, Lee JY. A quick test of cognitive speed in older adults with Alzheimer's disease and mild cognitive impairment: A preliminary behavioral and brain imaging study. Psychiatry Res Neuroimaging. 2018;280:30-38

2018

Park SM, Choi JS, Lee JS, Lee JY, Lee S, Jung HY. Impaired Executive Functioning of Sexual Assault Survivors with Acute Stress Disorder. J Clin Med. 2018;7(10):362

2018

Kang JM, Cho YS, Park S, Lee BH, Sohn BK, Choi CH, Choi JS, Jeong HY, Cho SJ, Lee JH, Lee JY. Montreal cognitive assessment reflects cognitive reserve. BMC Geriatr. 2018;18(1):261

2018

Lee JH, Byun MS, Yi D, Sohn BK, Jeon SY, Lee Y, Lee JY, Kim YK, Lee YS, Lee DY. Prediction of Cerebral Amyloid With Common Information Obtained From Memory Clinic Practice. Front Aging Neurosci. 2018;10:309

2018

Park S, Choi B, Choi C, Kang JM, Lee JY. Relationship between education, leisure activities, and cognitive functions in older adults. Aging Ment Health. 2018;23:1-10

2018

Lee J, Kim J, Shin SA, Park S, Yoon DH, Kim H, Kim YK, Moon MK, Koo BK, Lee JY. Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function. J Clin Med. 2018;7(11):413

2017

Kim YJ, Lee JY, Oh S, Park M, Jung HY, Sohn BK, Choi SW, Kim DJ, Choi JS.. Associations between prospective symptom changes and slow-wave activity in patients with Internet gaming disorder: A resting-state EEG study.. Medicine (Baltimore). 2017;96(8):1333

2017

Park SM, Lee JY, Kim YJ, Lee JY, Jung HY, Sohn BK, Kim DJ, Choi JS.. Neural connectivity in Internet gaming disorder and alcohol use disorder: A resting-state EEG coherence study.. Sci Rep. 2017;7(1):1333

2017

Shin KS, Yim YK, Kim Y, Park S, Lee JY . Effects of Visual Game Experience on Auditory Processing Speed. Cyberpsychol Behav Soc Netw. 2017;20(3):187-194

2017

Byun BH, Kim BI, Park SY, Ko IO, Lee KC, Kim KM, Kim YK, Lee JY, Bu SH, Kim JH, Chi DY, Ha JH, Lim SM.. Head-to-head comparison of 11C-PiB and 18F-FC119S for Aβ imaging in healthy subjects, mild cognitive impairment patients, and Alzheimer's disease patients.. Medicine (Baltimore). 2017;96(12):170

2017

Park S, Lee Y, Seong SJ, Chang SM, Lee JY, Hahm BJ, Hong JP.. A cross-sectional study about associations between personality characteristics and mental health service utilization in a Korean national community sample of adults with psychiatric disorders.. BMC Psychiatry. 2017;17(1):170

2017

Choi JS, Kim W, Sohn BK, Lee JY, Jung HY, Oh S, Joo SK, Kim HY, Jung YJ. Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C. Psychiatry Investig. 2017;14(3):314-324

2017

Lee JH, Byun MS, Yi D, Choe YM, Choi HJ, Baek H, Sohn BK, Lee JY, Kim HJ, Kim JW, Lee Y, Kim YK, Sohn CH, Woo JI, Lee DY; KBASE Research Group. Sex-specific association of sex hormones and gonadotropins, with brain amyloid and hippocampal neurodegeneration.. Neurobiol Aging. 2017;58:34-40

2017

Park S, Cho S, Lee JY. The effects of social concern goals on the value of learning and on the intentions of medical students to change their majors. Med Educ Online. 2017;22(1):1330631

2017

Yoon EJ, Choi JS, Kim H, Sohn BK, Jung HY, Lee JY, Kim DJ, Park SW, Kim YK. Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder.. Sci Rep. 2017;7(1):5744

2017

Kang SG, Na KS, Kang JM, Yeon BK, Lee JY, Cho SJ.. Dementia Care by Healthy Elderly Caregivers Is Associated with Improvement of Patients' Memory and the Caregivers' Quality of Life: A Before and After Study.. Psychiatry Investig. 2017;14(4):458-462

2017

Lee C, Lee K, Yu H, Ryu SH, Moon SW, Han C, Lee JY, Lee YM, Kim SG, Kim KW, Lee DW, Kim SY, Lee SY, Bae JN, Jung YE, Kim JL, Kim BS, Shin IS, Kim YH, Kim BJ, Kang HS, Myung W, Carroll BJ, Kim DK. Adverse Events With Sustained-Release Donepezil in Alzheimer Disease: Relation to Body Mass Index.. J Clin Psychopharmacol. 2017;37(4):401-404

2017

Choi HJ, Byun MS, Yi D, Sohn BK, Lee JH, Lee JY, Kim YK, Lee DY; KBASE Research Group.. Associations of thyroid hormone serum levels with in-vivo Alzheimer's disease pathologies.. Alzheimers Res Ther. 2017;9(1):64

2017

Kim SY, Jeon YJ, Lee JY, Kim YH.. Characteristics of tinnitus in adolescents and association with psychoemotional factors.. Laryngoscope. 2017;127(9):2113-2119

2017

Park S, Kim T, Shin SA, Kim YK, Sohn BK, Park HJ, Youn JH, Lee JY.. Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Dementia.. Front Aging Neurosci. 2017;30(9):389

2017

Byun MS, Kim HJ, Yi D, Choi HJ, Baek H, Lee JH, Choe YM, Sohn BK, Lee JY, Lee Y, Ko H, Kim YK, Lee YS, Sohn CH, Woo JI, Lee DY; KBASE Research Group.. Differential effects of blood insulin and HbA1c on cerebral amyloid burden and neurodegeneration in nondiabetic cognitively normal older adults.. Neurobiol Aging. 2017;59:15-21

2017

Byun MS, Yi D, Lee JH, Choe YM, Sohn BK, Lee JY, Choi HJ, Baek H, Kim YK, Lee YS, Sohn CH, Mook-Jung I, Choi M, Lee YJ, Lee DW, Ryu SH, Kim SG, Kim JW, Woo JI, Lee DY; KBASE Research Group.. Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics. Psychiatry Investig. 2017;14(6):851-863