Research Overview

2022-06

Yoo A, Joo Y, Cheon Y, Lee SJ, Lee S. Neuronal growth regulator 1 promotes adipocyte lipid trafficking via interaction with CD36. J Lipid Res. 2022 Jun; 63(6):100221.

2022-03

Oh J, Cho W-H, E. Barcelon, Kim KH, Hong J, Lee SJ. SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. Scientific Reports. 2022.

2021-11

Choi B, Ahn M-H, Hong S, E. E. Barcelon, J. Sangshetti, R. B. Arote, Lee SJ. Development of novel, biocompatible, polyester amines for microglia-targeting gene delivery. RSC Advances. 2021

2021-06

Song B, Lee S-J, Kim C-H. Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model. Int J Mol Sci. 2021 Jun 25; 22(13)6853.

2021-05

Lee J, Hwang H, Lee SJ. Distinct roles of GT1b and CSF-1 in microglia activation in nerve injury-induced neuropathic pain. Mol Pain. 2021 May 30; 17:1-8

2021-01

Jo YR, Kim HR, Jang SY, Go H, Song MY, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon SM, Lee HK, Lee KE, Kim YH, Park HT. Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB J. 2021 Jan;35(1):e21225.

2020-07-15

Park K, Lee SJ. Deciphering the star codings: astrocyte manipulation alters mouse behavior. Exp Mol Med. 2020 Jul 15;52(7):1028-1038.

2020-02-29

Noh K, Park JC, Han JS, Lee SJ. From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric Disorders. Exp Neurobiol. 2020 Feb 29;29(1):1-10.

2020-02-06

Lim H, Lee J, You B, Oh JH, Mok HJ, Kim YS, Yoon BE, Kim BG, Back SK, Park JS, Kim KP, Schnaar RL, Lee SJ. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain. EMBO J. 2020 Feb 6:e102214.

2020-01-04

Won S, Park K, Lim H, Lee SJ. Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain. Behav Brain Funct. 2020 Jan 4;16(1):1.

2019-10-25

Choi B, Soh M, Manandhar Y, Kim D, Han SI, Baik S, Shin K, Koo S, Kwon HJ, Ko G, Oh J, Hwang H, Hyeon T, Lee SJ. Highly selective microglial uptake of ceria-zirconia nanoparticles for enhanced analgesic treatment of neuropathic pain. Nanoscale. 2019 Oct 25;11(41):19437-19447.

2019-09

Joo Y, Kim H, Lee SJ, Lee S.Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass. Int J Obes (Lond). 2019 Sep;43(9):1769-1782.

2019-08-24

Noh K, Lee H, Choi T-Y, Joo Y, Kim S-J, Kim H, Kim JY, Jahng JW, Lee S, Choi S-Y, Lee SJ. Negr1 controls adult hippocampal neurogenesis and affective behaviors Mol. Psychiatry. 2019 Aug;24(8):1189-1205.

2019-08

Noh K, Lee H, Choi TY, Joo Y, Kim SJ, Kim H, Kim JY, Jahng JW, Lee S, Choi SY, Lee SJ. Negr1 regulates hippocampal Lcn2 expression and affective behaviour via interaction with LIF receptor. Mol. Psychiatry. 2019 Aug;24(8):1095.

2019-03-15

Barcelon EE, Cho WH, Jun SB, Lee SJ. Brain Microglial Activation in Chronic Pain-Associated Affective Disorder. Front Neurosci. 2019 Mar 15;13:213. doi: 10.3389/fnins.2019.00213.

2019-03-07

Jang M, Choi JH, Chang Y, Lee SJ, Nah SY, Cho IH. Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors. Brain Behav Immun. 2019 Mar 7. pii: S0889-1591(18)30392-1. doi: 10.1016/j.bbi.2019.03.001

2019-03

Lee JW, Nam H, Kim LE, Jeon Y, Min H, Ha S, Lee Y, Kim SY, Lee SJ, Kim EK, Yu SW. TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia. Autophagy. 2019 May;15(5):753-770

2018-10

Min H, Cho WH, Lee H, Choi B, Lee HK, Kim YJ, Joo Y, Jung SJ, Choi SY, Lee S, Lee SJ. Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization. Mol Pain. 2018 Oct 25:1744806918812636. doi: 10.1177/1744806918812636.

2018-09

Kim D, Yoo JM, Hwang H, Lee J, Lee SH, Yun SP, Park MJ, Lee M, Choi S, Kwon SH, Lee S, Kwon SH, Kim S, Park YJ, Kinoshita M, Lee YH, Shin S, Paik SR, Lee SJ, Lee S, Hong BH, Ko HS. Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease. Nat Nanotechnol. 2018 Sep;13(9):812-818

2018-09

Nho B, Lee J, Lee J, Ko KR, Lee SJ, Kim S. Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model. FASEB J. 2018 Sep;32(9):5119-5131

2018-01

Shin WG, Park BJ, Lee SJ, Kim JG. Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1. Korean J Intern Med. 2018

2017-09

Lim H, Lee H, Noh K, Lee SJ. IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury. Pain. 2017 Sep; 158(9):1666-1677

2017-06-24

. Min H, Choi B, Jang YH, Cho IH, Lee SJ. Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage. Mol Brain. 2017 Jun 24;10(1):27

2017-01-22

Kim H, Chun Y, Che L, Kim J, Lee S, Lee S. The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking. Biochem Biophys Res Commun. 2017 Jan 22; 482(4):1367-1374

2017-01

Kim H, Choi B, Lim H, Min H, Oh JH, Choi S, Cho JG, Park JS, Lee SJ. Polyamidoamine dendrimer-conjugated triamcinolone acetonide attenuates nerve injury-induced spinal cord microglia activation and mechanical allodynia. Mol Pain. 2017 Jan 13; 13:1-11