Research Overview

2022

Song CW, Kim H, Cho H, Kim MS, Paek SH, Park HJ, Griffin RJ, Terezakis S, Cho LC. HIF-1α Inhibition Improves Anti-Tumor Immunity and Promotes the Efficacy of Stereotactic Ablative Radiotherapy (SABR). Cancers (Basel). 2022 Jul 4;14(13):3273.

2022

Varn FS, Johnson KC, Martinek J, Huse JT, Nasrallah MP, Wesseling P, Cooper LAD, Malta TM, Wade TE, Sabedot TS, Brat D, Gould PV, Wöehrer A, Aldape K, Ismail A, Sivajothi SK, Barthel FP, Kim H, Kocakavuk E, Ahmed N, White K, Datta I, Moon HE, Pollock S, Goldfarb C, Lee GH, Garofano L, Anderson KJ, Nehar-Belaid D, Barnholtz-Sloan JS, Bakas S, Byrne AT, D'Angelo F, Gan HK, Khasraw M, Migliozzi S, Ormond DR, Paek SH, Van Meir EG, Walenkamp AME, Watts C, Weiss T, Weller M, Palucka K, Stead LF, Poisson LM, Noushmehr H, Iavarone A, Verhaak RGW; GLASS Consortium. Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell. 2022 May 24:S0092-8674(22)00536-0.

2022

Jeong JY, Park H, Yoo H, Kim EJ, Jeon B, Lee JD, Kang D, Lee CJ, Paek SH, Roh EJ, Yi GS, Kang SS. Trifluoperazine and Its Analog Suppressed the Tumorigenicity of Non-Small Cell Lung Cancer Cell; Applicability of Antipsychotic Drugs to Lung Cancer Treatment. Biomedicines. 2022 Apr 30;10(5):1046.

2022

Jeon H, Lee H, Kwon DH, Kim J, Tanaka-Yamamoto K, Yook JS, Feng L, Park HR, Lim YH, Cho ZH, Paek SH, Kim J. Topographic connectivity and cellular profiling reveal detailed input pathways and functionally distinct cell types in the subthalamic nucleus. Cell Rep. 2022 Mar 1;38(9):110439.

2022

Kwon T, Ra JS, Lee S, Baek IJ, Khim KW, Lee EA, Song EK, Otarbayev D, Jung W, Park YH, Wie M, Bae J, Cheng H, Park JH, Kim N, Seo Y, Yun S, Kim HE, Moon HE, Paek SH, Park TJ, Park YU, Rhee H, Choi JH, Cho SW, Myung K. Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2103532119.

2021

Kwon DH, Paek SH, Kim YB, Lee H, Cho ZH. In vivo 3D Reconstruction of the Human Pallidothalamic and Nigrothalamic Pathways With Super-Resolution 7T MR Track Density Imaging and Fiber Tractography. Front Neuroanat. 2021 Oct 27;15:739576.

2021

Jo A, Lee Y, Kam TI, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jiang H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Sci Transl Med. 2021 Jul 28;13(604):eaax8891.

2021

Shin HY, Han KS, Park HW, Hong YH, Kim Y, Moon HE, Park KW, Park HR, Lee CJ, Lee K, Kim SJ, Heo MS, Park SH, Kim DG, Paek SH. Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling. Exp Neurobiol. 2021 Apr 30;30(2):120-143. (Corresponding)

2021

Lee SJ, Choi YJ, Kim HI, Moon HE, Paek SH, Kim TY, Ko SG. Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation. Mol Oncol. 2021 May 1.

2021

Park K, Park KH, Park HR, Lee JM, Kim YH, Kim DY, Won TB, Kong SH, Kim JH, Shin CS, Paek SH. Long-term Outcome of Microscopic Transsphenoidal Surgery for Prolactinomas as an Alternative to Dopamine Agonists. J Korean Med Sci. 2021 Apr 19;36(15):e97. (Corresponding)

2021

Kim A, Kim HJ, Kim A, Kim Y, Jang M, Paek SH, Jeon B. Bilateral subthalamic nucleus deep brain stimulation is an effective treatment for diphasic dyskinesia. Eur J Neurol. 2021 Jan 29. (Co-corresponding)

2021

Park KH, Sun S, Lim YH, Park HR, Lee JM, Park K, Jeon B, Park HP, Kim HC, Paek SH. Clinical outcome prediction from analysis of microelectrode recordings using deep learning in subthalamic deep brain stimulation for Parkinson`s disease. PLoS One. 2021 Jan 26;16(1):e0244133. (Co-corresponding)

2021-03-24

Kim Y, Varn FS, Park SH, Yoon BW, Park HR, Lee C, Verhaak RGW, Paek SH. Perspective of mesenchymal transformation in glioblastoma. Acta Neuropathol Commun. 2021 Mar 24;9(1):50.

2020-09

Yang J, Moon HE, Park HW, McDowell A, Shin TS, Jee YK, Kym S, Paek SH, Kim YK. Brain tumor diagnostic model and dietary effect based on extracellular vesicle microbiome data in serum. Exp Mol Med. 2020 Sep;52(9):1602-1613.

2020-06-12

Park HW, Park CG, Park M, Lee SH, Park HR, Lim J, Paek SH, Choy YB. Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model. Sci Rep. 2020 Jun 12;10(1):9572.

2020-04

Shih DJH, Nayyar N, Bihun I, Dagogo-Jack I, Gill CM, Aquilanti E, Bertalan M, Kaplan A, D'Andrea MR, Chukwueke U, Ippen FM, Alvarez-Breckenridge C, Camarda ND, Lastrapes M, McCabe D, Kuter B, Kaufman B, Strickland MR, Martinez-Gutierrez JC, Nagabhushan D, De Sauvage M, White MD, Castro BA, Hoang K, Kaneb A, Batchelor ED, Paek SH, Park SH, Martinez-Lage M, Berghoff AS, Merrill P, Gerstner ER, Batchelor TT, Frosch MP, Frazier RP, Borger DR, Iafrate AJ, Johnson BE, Santagata S, Preusser M, Cahill DP, Carter SL, Brastianos PK. Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma. Nat Genet. 2020 Apr;52(4):371-377.

2020-04-23

Han S, Kim S, Chen Z, Shin HK, Lee SY, Moon HE, Paek SH, Park S. 3D Bioprinted Vascularized Tumour for Drug Testing. Int J Mol Sci. 2020 Apr 23;21(8):2993

2020-03-15

Kim BH, Lee H, Park CG, Jeong AJ, Lee SH, Noh KH, Park JB, Lee CG, Paek SH, Kim H, Ye SK. STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model. Cells. 2020 Mar 15;9(3):722.

2020-01

Heo JY, Nam MH, Yoon HH, Kim J, Hwang YJ, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H, Jeon SR, Lee CJ. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol 2020 Jan 20;30(2):276-291.

2019-04

Lee J, Jo DH, Kim JH, Cho CS, Han JE, Kim Y, Park H, Yoo SH, Yu YS, Moon HE, Park HR, Kim DG, Kim JH, Paek SH. Development of a patient-derived xenograft model of glioblastoma via intravitreal injection in mice. Exp Mol Med. 2019 Apr 16;51(4):1-9.

2019-03

Jang JT, Lee J, Seon J, Ju E, Kim M, Kim YI, Kim MG, Takemura Y, Arbab AS, Kang KW, Park KH, Paek SH, Bae S. Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe2 O3 Superparamagnetic Nanoparticles for Completely Killing Tumors. Adv Mater. 2019 Mar;31(12):e1806347.

2018-02

Jang JT, Lee J, Seon J, Ju E, Kim M, Kim YI, Kim MG, Takemura Y, Arbab AS, Kang KW, Park KH, Paek SH, Bae S. Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe2 O3 Superparamagnetic Nanoparticles for Completely Killing Tumors. Adv Mater. 2018 Feb;30(6).

2017-04-14

Cho SY, Park C, Na D, Han JY, Lee J, Park OK, Zhang C, Sung CO, Moon HE, Kim Y, Kim JH, Kim JJ, Khang SK, Nam DH, Choi JW, Suh YL, Kim DG, Park SH, Youn H, Yun K, Kim JI, Lee C, Paek SH, Park H. High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients. Exp Mol Med. 2017 Apr 14;49(4):e317.

2017-01

Kang S, Hong J, Lee JM, Moon HE, Jeon B, Choi J, Yoon NA, Paek SH, Roh EJ, Lee CJ, Kang SS. Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R. Mol Cancer Ther. 2017 Jan;16(1):217-227.