Research Overview

2021

Wulansari N, Darsono WHW, Woo HJ, Chang MY, Kim J, Bae EJ, Sun W, Lee JH, Cho IJ, Shin H, Lee SJ*, Lee SH*. Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked DNAJC6 mutations. Sci Adv. 2021 doi: 10.1126/sciadv.abb1540. (*co-corresponding authors)

2019

Timo Strohäker, Byung Chul Jung, Shu-Hao Liou, Claudio O. Fernandez, Dietmar Riedel, Stefan Becker, Glenda M. Halliday, Marina Bennati, Woojin S. Kim*,Seung-Jae Lee*, and Markus Zweckstetter*. Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nat Commun. 2019;10(1):5535. doi: 10.1038/s41467-019-13564-w. (*co-corresponding authors)

2019

Jun Sung Lee, Kazuaki Kanai, Mari Suzuki, Woojin S. Kim, Han Soo Yoo, YuHong Fu, Dong-Kyu Kim, Byung Chul Jung, Minsun Choi, Kyu Won Oh, Yuanzhe Li, Mitsuyoshi Nakatani, Tomoko Nakazato, Satoko Sekimoto, Manabu Funayama, Hiroyo Yoshino, Shin-ichiro Kubo, Kenya Nishioka, Ryusuke Sakai, Morio Ueyama, Hideki Mochizuki, He-Jin Lee, Sergio Pablo Sardi, Glenda M. Halliday, Yoshitaka Nagai, Phil Hyu Lee, Nobutaka Hattori and Seung-Jae Lee. Arylsulfatase A, a genetic modifier of Parkinson’s disease, is an a-synuclein chaperone. BRAIN. 2019, doi: 10.1093/brain/awz205

2018

Bae E-J, Kim D-K, Kim C, Mante M, Adame A, Rockenstein E, Ulusoy A, Klinkenberg M, Jeong GR, Bae JR, Lee C, Lee H-J, Lee B-D, Di Monte DA, Masliah E, Lee S-J. LRRK2 kinase regulates -synuclein propagation via RAB35 phosphorylation. Nature Commun, 9(1):3465. doi: 10.1038/s41467-018-05958-z

2018

Lim S, Kim H-J, Kim D-K, Lee S-J. Non-cell-autonomous actions of alpha-synuclein: implications in glial synucleinopathies. Prog Neurobiol, 2018, 169, 158-171

2016

Kim DK, Lim HS, Kawasaki I, Shim YH, Vaikath NN, El-Agnaf OMA, Lee HJ, Lee S-J. Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function. Autophagy, 2016, 12, 1849-1863

2015

Kim C, Rockenstein E, Spencer B, Kim H-K, Adame A, Trejo M, Stafa K, Lee H-J, Lee S-J,*, Masliah E,* (2015) Antagonizing neuronal Toll-like receptor 2 prevents synucleinopathy by activating autophagy. Cell Reports, 13, 771-782 *Co-corresponding authors

2015

Lee S-J, Masliah E (2015) Aggregates feel the strain. Nature, 522, 296-297

2014

Bae E-J, Yang N-Y, Song M, Lee CS, Lee H-J, Masliah E, Sardi SP, Lee S-J (2014) Glucocerebrosidase deficiency enhances cell-to-cell transmission of -synuclein. Nature Communications, 5:4755 doi: 10.1038/ncomms5755

2014

Lee H-J, Bae E-J, Lee S-J. (2014) Extracelullar a-synuclein: A novel and crucial factor in Lewy body diseases. Nature Rev. Neurol., doi:10.1038/nrneurol.2013.275

2013

Kim C, Ho D-H, Suk J-E, You S, Michael S, Kang J, Lee S, Masliah E, Hwang D, Lee H-J, Lee S-J (2013) Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nature Commun. 4:1562 | DOI: 10.1038/ncomms2534

2010

Lee S-J, Desplats P, Sigurdson C, Tsigelny I, Masliah E (2010) Cell-Cell Transmission of Non-Prion Protein Aggregates, Nature Review Neurology, 6, 702-706

2009

Desplats P*, Lee H-J*, Bae E-J, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee S-J (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc. Nat. Acad. Sci. USA, 106, 13010-13015 (* equal contribution) Cover highlight